diff --git a/Content.Server/Chemistry/ReagentEffects/GenderChange.cs b/Content.Server/Chemistry/ReagentEffects/GenderChange.cs
new file mode 100644
index 0000000000..7c0cc07469
--- /dev/null
+++ b/Content.Server/Chemistry/ReagentEffects/GenderChange.cs
@@ -0,0 +1,49 @@
+using Content.Server.IdentityManagement;
+using Content.Shared._Amour.GrammarSystem;
+using Content.Shared.Chemistry.Reagent;
+using Content.Shared.IdentityManagement.Components;
+using Robust.Shared.Enums;
+using Robust.Shared.Prototypes;
+using Robust.Shared.GameObjects.Components.Localization;
+
+namespace Content.Server.Chemistry.ReagentEffects;
+
+public sealed partial class GenderChange : ReagentEffect
+{
+    /// <summary>
+    ///     What gender is the consumer changed to? If not set then swap between male/female.
+    /// </summary>
+    [DataField("gender")]
+    public Gender? NewGender;
+
+    protected override string? ReagentEffectGuidebookText(IPrototypeManager prototype, IEntitySystemManager entSys)
+        => Loc.GetString("reagent-effect-guidebook-gender-change", ("chance", Probability));
+
+    public override void Effect(ReagentEffectArgs args)
+    {
+        if (args.EntityManager.TryGetComponent<GrammarComponent>(args.SolutionEntity, out var grammar))
+        {
+            var uid = args.SolutionEntity;
+            var newGender = NewGender;
+            var grammarSystem = args.EntityManager.System<GrammarSystem>();
+            var identitySystem = args.EntityManager.System<IdentitySystem>();
+
+            // bleh, this probably should not be here but I have no clue where to put it
+            if (grammar.Gender != Gender.Epicene && grammar.Gender != Gender.Neuter)
+            {
+                if (grammar.Gender == Gender.Male)
+                    newGender = Gender.Female;
+                else
+                    newGender = Gender.Male;
+            }
+
+            if (newGender.HasValue)
+            {
+                grammarSystem.SetGender((uid, grammar), newGender);
+
+                if (args.EntityManager.HasComponent<IdentityComponent>(uid))
+                    identitySystem.QueueIdentityUpdate(uid);
+            }
+        }
+    }
+}
diff --git a/Content.Server/Chemistry/ReagentEffects/SexChange.cs b/Content.Server/Chemistry/ReagentEffects/SexChange.cs
new file mode 100644
index 0000000000..6ba69e23ae
--- /dev/null
+++ b/Content.Server/Chemistry/ReagentEffects/SexChange.cs
@@ -0,0 +1,36 @@
+using Content.Shared.Humanoid;
+using Content.Shared.Chemistry.Reagent;
+using Robust.Shared.Prototypes;
+
+namespace Content.Server.Chemistry.ReagentEffects;
+
+public sealed partial class SexChange : ReagentEffect
+{
+    /// <summary>
+    ///     What sex is the consumer changed to? If not set then swap between male/female.
+    /// </summary>
+    [DataField("sex")]
+    public Sex? NewSex;
+
+    protected override string? ReagentEffectGuidebookText(IPrototypeManager prototype, IEntitySystemManager entSys)
+        => Loc.GetString("reagent-effect-guidebook-sex-change", ("chance", Probability));
+
+    public override void Effect(ReagentEffectArgs args)
+    {
+        if (args.EntityManager.TryGetComponent<HumanoidAppearanceComponent>(args.SolutionEntity, out var appearance))
+        {
+            var uid = args.SolutionEntity;
+            var newSex = NewSex;
+            var humanoidAppearanceSystem = args.EntityManager.System<SharedHumanoidAppearanceSystem>();
+
+            if (newSex.HasValue)
+            {
+                humanoidAppearanceSystem.SetSex(uid, newSex.Value);
+                return;
+            }
+
+            if (appearance.Sex != Sex.Unsexed)
+                humanoidAppearanceSystem.SwapSex(uid);
+        }
+    }
+}
diff --git a/Content.Shared/Humanoid/SharedHumanoidAppearanceSystem.cs b/Content.Shared/Humanoid/SharedHumanoidAppearanceSystem.cs
index 4bab12dcfb..8c98f71591 100644
--- a/Content.Shared/Humanoid/SharedHumanoidAppearanceSystem.cs
+++ b/Content.Shared/Humanoid/SharedHumanoidAppearanceSystem.cs
@@ -359,6 +359,21 @@ public abstract class SharedHumanoidAppearanceSystem : EntitySystem
         }
     }
 
+    public void SwapSex(EntityUid uid, HumanoidAppearanceComponent? humanoid = null)
+    {
+        if (!Resolve(uid, ref humanoid) || humanoid.Sex == Sex.Unsexed)
+            return;
+
+        // Not set up for future possible alien sexes
+        if (humanoid.Sex == Sex.Male)
+        {
+            SetSex(uid,Sex.Female);
+            return;
+        }
+        SetSex(uid,Sex.Male);
+
+    }
+
     public List<BodyTypePrototype> GetValidBodyTypes(SpeciesPrototype species, Sex sex)
     {
         return species.BodyTypes.Select(protoId => _proto.Index<BodyTypePrototype>(protoId))
diff --git a/Content.Shared/_Amour/GrammarSystem/GrammarSystem.cs b/Content.Shared/_Amour/GrammarSystem/GrammarSystem.cs
new file mode 100644
index 0000000000..7d9bc2fef3
--- /dev/null
+++ b/Content.Shared/_Amour/GrammarSystem/GrammarSystem.cs
@@ -0,0 +1,39 @@
+using System.Diagnostics.CodeAnalysis;
+using Robust.Shared.Enums;
+using Robust.Shared.GameObjects.Components.Localization;
+
+namespace Content.Shared._Amour.GrammarSystem;
+
+public sealed class GrammarSystem : EntitySystem
+{
+    public void Clear(Entity<GrammarComponent> grammar)
+    {
+        grammar.Comp.Attributes.Clear();
+        Dirty(grammar);
+    }
+
+    public bool TryGet(Entity<GrammarComponent> grammar, string key, [NotNullWhen(true)] out string? value)
+    {
+        return grammar.Comp.Attributes.TryGetValue(key, out value);
+    }
+
+    public void Set(Entity<GrammarComponent> grammar, string key, string? value)
+    {
+        if (value == null)
+            grammar.Comp.Attributes.Remove(key);
+        else
+            grammar.Comp.Attributes[key] = value;
+
+        Dirty(grammar);
+    }
+
+    public void SetGender(Entity<GrammarComponent> grammar, Gender? gender)
+    {
+        Set(grammar, "gender", gender?.ToString());
+    }
+
+    public void SetProperNoun(Entity<GrammarComponent> grammar, bool? proper)
+    {
+        Set(grammar, "proper", proper?.ToString());
+    }
+}
diff --git a/Resources/Locale/ru-RU/guidebook/chemistry/effects.ftl b/Resources/Locale/ru-RU/guidebook/chemistry/effects.ftl
index f09ac1c15a..6d3a3321a1 100644
--- a/Resources/Locale/ru-RU/guidebook/chemistry/effects.ftl
+++ b/Resources/Locale/ru-RU/guidebook/chemistry/effects.ftl
@@ -321,3 +321,15 @@ reagent-effect-guidebook-missing =
         [1] Causes
        *[other] cause
     } an unknown effect as nobody has written this effect yet
+
+#Amour
+reagent-effect-guidebook-sex-change =
+    { $chance ->
+    [1] Делает
+    *[other] делает
+        } метаболизатор меняет пол
+reagent-effect-guidebook-gender-change =
+    { $chance ->
+    [1] Делает
+    *[other] делает
+        } метаболизатор меняет пол
diff --git a/Resources/Locale/ru-RU/reagents/meta/fun.ftl b/Resources/Locale/ru-RU/reagents/meta/fun.ftl
index c460b83366..8c248a854f 100644
--- a/Resources/Locale/ru-RU/reagents/meta/fun.ftl
+++ b/Resources/Locale/ru-RU/reagents/meta/fun.ftl
@@ -10,3 +10,9 @@ reagent-name-saxoite = саксонит
 reagent-desc-saxoite = Отдаёт джазом.
 reagent-name-licoxide = ликоксид
 reagent-desc-licoxide = Это выглядит... электризующе.
+reagent-name-estrogen-plus = Эстроген Плюс
+reagent-desc-estrogen-plus = Эстроген... плюс тестостерон... как это работает?..
+reagent-name-estrogen = Эстроген
+reagent-desc-estrogen = Средство для выражения вашей женской натуры.
+reagent-name-testosterone = Тестостерон
+reagent-desc-testosterone = Химическое вещество, выражающее вашу мужскую сторону.
diff --git a/Resources/Prototypes/Hydroponics/mutations.yml b/Resources/Prototypes/Hydroponics/mutations.yml
index 17617f5ee3..5c78eab547 100644
--- a/Resources/Prototypes/Hydroponics/mutations.yml
+++ b/Resources/Prototypes/Hydroponics/mutations.yml
@@ -32,6 +32,7 @@
     - ChangelingSting
     - CogChamp
     - JuiceThatMakesYouWeh
+    - EstrogenPlus
   - quantity: 5
     weight: 2
     reagents:
diff --git a/Resources/Prototypes/Reagents/fun.yml b/Resources/Prototypes/Reagents/fun.yml
index befa8d8296..e371223aa9 100644
--- a/Resources/Prototypes/Reagents/fun.yml
+++ b/Resources/Prototypes/Reagents/fun.yml
@@ -348,3 +348,103 @@
         conditions:
         - !type:ReagentThreshold
           min: 50
+
+- type: reagent
+  id: EstrogenPlus
+  name: reagent-name-estrogen-plus
+  desc: reagent-desc-estrogen-plus
+  physicalDesc: reagent-physical-desc-soothing
+  flavor: medicine
+  color: "#ffffff"
+  metabolisms:
+    Medicine:
+      effects:
+      - !type:SexChange
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:GenderChange
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:AdjustReagent
+        reagent: EstrogenPlus
+        amount: -20
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:PopupMessage
+        type: Local
+        messages: [ "generic-reagent-effect-changed" ]
+        conditions:
+        - !type:ReagentThreshold
+          reagent: EstrogenPlus
+          min: 20
+
+- type: reagent
+  id: Estrogen
+  name: reagent-name-estrogen
+  desc: reagent-desc-estrogen
+  physicalDesc: reagent-physical-desc-enigmatic
+  flavor: medicine
+  color: "#f5aab9"
+  metabolisms:
+    Medicine:
+      effects:
+      - !type:SexChange
+        sex: Female
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:GenderChange
+        gender: Female
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:AdjustReagent
+        reagent: Estrogen
+        amount: -20
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:PopupMessage
+        type: Local
+        messages: [ "generic-reagent-effect-changed" ]
+        conditions:
+        - !type:ReagentThreshold
+          reagent: Estrogen
+          min: 20
+
+- type: reagent
+  id: Testosterone
+  name: reagent-name-testosterone
+  desc: reagent-desc-testosterone
+  physicalDesc: reagent-physical-desc-enigmatic
+  flavor: medicine
+  color: "#5bcffa"
+  metabolisms:
+    Medicine:
+      effects:
+      - !type:SexChange
+        sex: Male
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:GenderChange
+        gender: Male
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:AdjustReagent
+        reagent: Testosterone
+        amount: -20
+        conditions:
+        - !type:ReagentThreshold
+          min: 20
+      - !type:PopupMessage
+        type: Local
+        messages: [ "generic-reagent-effect-changed" ]
+        conditions:
+        - !type:ReagentThreshold
+          reagent: Testosterone
+          min: 20
diff --git a/Resources/Prototypes/Recipes/Construction/fun.yml b/Resources/Prototypes/Recipes/Construction/fun.yml
index a8dada9955..9f55289ae0 100644
--- a/Resources/Prototypes/Recipes/Construction/fun.yml
+++ b/Resources/Prototypes/Recipes/Construction/fun.yml
@@ -8,3 +8,26 @@
   description: An air horn made from bananium.
   icon: { sprite: Objects/Fun/bananiumhorn.rsi, state: icon }
   objectType: Item
+
+- type: reaction
+  id: EstrogenPlus
+  reactants:
+    Testosterone:
+      amount: 1
+    Estrogen:
+      amount: 1
+  products:
+    EstrogenPlus: 1
+
+# Terraria gender swap potion reference? teheh
+- type: reaction
+  id: EstrogenPlusFlower
+  reactants:
+    Bicaridine:
+      amount: 1
+    Siderlac:
+      amount: 1
+    PolypyryliumOligomers:
+      amount: 1
+  products:
+    EstrogenPlus: 1