diff --git a/Content.Server/Chemistry/Components/InjectorComponent.cs b/Content.Server/Chemistry/Components/InjectorComponent.cs
index aab8a633d5..446f6e935a 100644
--- a/Content.Server/Chemistry/Components/InjectorComponent.cs
+++ b/Content.Server/Chemistry/Components/InjectorComponent.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Threading;
 using System.Threading.Tasks;
 using Content.Server.Administration.Logs;
 using Content.Server.Body.Components;
@@ -64,9 +65,10 @@ namespace Content.Server.Chemistry.Components
         public float Delay = 5;
 
         /// <summary>
-        /// Is this component currently being used in a DoAfter?
+        ///     Token for interrupting a do-after action (e.g., injection another player). If not null, implies
+        ///     component is currently "in use".
         /// </summary>
-        public bool InUse = false;
+        public CancellationTokenSource? CancelToken;
 
         private InjectorToggleMode _toggleState;
 
@@ -127,8 +129,11 @@ namespace Content.Server.Chemistry.Components
         /// <param name="eventArgs"></param>
         async Task<bool> IAfterInteract.AfterInteract(AfterInteractEventArgs eventArgs)
         {
-            if (InUse)
-                return false;
+            if (CancelToken != null)
+            {
+                CancelToken.Cancel();
+                return true;
+            }
 
             if (!eventArgs.InRangeUnobstructed(ignoreInsideBlocker: true, popup: true))
                 return false;
@@ -197,7 +202,6 @@ namespace Content.Server.Chemistry.Components
         /// </summary>
         public async Task<bool> TryInjectDoAfter(EntityUid user, EntityUid target)
         {
-            InUse = true;
             var popupSys = EntitySystem.Get<SharedPopupSystem>();
 
             // Create a pop-up for the user
@@ -249,8 +253,9 @@ namespace Content.Server.Chemistry.Components
                     //TODO solution pretty string.
             }
 
+            CancelToken = new();
             var status = await EntitySystem.Get<DoAfterSystem>().WaitDoAfter(
-                new DoAfterEventArgs(user, actualDelay, target: target)
+                new DoAfterEventArgs(user, actualDelay, CancelToken.Token, target)
                 {
                     BreakOnUserMove = true,
                     BreakOnDamage = true,
@@ -258,7 +263,7 @@ namespace Content.Server.Chemistry.Components
                     BreakOnTargetMove = true,
                     MovementThreshold = 1.0f
                 });
-            InUse = false;
+            CancelToken = null;
 
             return status == DoAfterStatus.Finished;
         }
diff --git a/Content.Server/Chemistry/EntitySystems/InjectorSystem.cs b/Content.Server/Chemistry/EntitySystems/InjectorSystem.cs
index e4affc4678..19bc66986e 100644
--- a/Content.Server/Chemistry/EntitySystems/InjectorSystem.cs
+++ b/Content.Server/Chemistry/EntitySystems/InjectorSystem.cs
@@ -1,6 +1,8 @@
-using Content.Server.Chemistry.Components;
+using Content.Server.Chemistry.Components;
+using Content.Shared.Hands;
 using JetBrains.Annotations;
 using Robust.Shared.GameObjects;
+using System;
 
 namespace Content.Server.Chemistry.EntitySystems
 {
@@ -12,6 +14,16 @@ namespace Content.Server.Chemistry.EntitySystems
             base.Initialize();
 
             SubscribeLocalEvent<InjectorComponent, SolutionChangedEvent>(OnSolutionChange);
+            SubscribeLocalEvent<InjectorComponent, HandDeselectedEvent>(OnInjectorDeselected);
+        }
+
+        private void OnInjectorDeselected(EntityUid uid, InjectorComponent component, HandDeselectedEvent args)
+        {
+            if (component.CancelToken != null)
+            {
+                component.CancelToken.Cancel();
+                component.CancelToken = null;
+            }
         }
 
         private void OnSolutionChange(EntityUid uid, InjectorComponent component, SolutionChangedEvent args)
diff --git a/Content.Server/DoAfter/DoAfterSystem.cs b/Content.Server/DoAfter/DoAfterSystem.cs
index e64afc9456..ea301b9743 100644
--- a/Content.Server/DoAfter/DoAfterSystem.cs
+++ b/Content.Server/DoAfter/DoAfterSystem.cs
@@ -12,8 +12,8 @@ namespace Content.Server.DoAfter
     public sealed class DoAfterSystem : EntitySystem
     {
         // We cache these lists as to not allocate them every update tick...
-        private readonly List<DoAfter> _cancelled = new();
-        private readonly List<DoAfter> _finished = new();
+        private readonly Queue<DoAfter> _cancelled = new();
+        private readonly Queue<DoAfter> _finished = new();
 
         public override void Initialize()
         {
@@ -52,17 +52,17 @@ namespace Content.Server.DoAfter
                         case DoAfterStatus.Running:
                             break;
                         case DoAfterStatus.Cancelled:
-                            _cancelled.Add(doAfter);
+                            _cancelled.Enqueue(doAfter);
                             break;
                         case DoAfterStatus.Finished:
-                            _finished.Add(doAfter);
+                            _finished.Enqueue(doAfter);
                             break;
                         default:
                             throw new ArgumentOutOfRangeException();
                     }
                 }
 
-                foreach (var doAfter in _cancelled)
+                while (_cancelled.TryDequeue(out var doAfter))
                 {
                     comp.Cancelled(doAfter);
 
@@ -76,7 +76,7 @@ namespace Content.Server.DoAfter
                         RaiseLocalEvent(doAfter.EventArgs.BroadcastCancelledEvent);
                 }
 
-                foreach (var doAfter in _finished)
+                while (_finished.TryDequeue(out var doAfter))
                 {
                     comp.Finished(doAfter);
 
@@ -89,10 +89,6 @@ namespace Content.Server.DoAfter
                     if(doAfter.EventArgs.BroadcastFinishedEvent != null)
                         RaiseLocalEvent(doAfter.EventArgs.BroadcastFinishedEvent);
                 }
-
-                // Clean the shared lists at the end, ensuring they'll be clean for the next time we need them.
-                _cancelled.Clear();
-                _finished.Clear();
             }
         }
 
diff --git a/Content.Server/Nutrition/Components/DrinkComponent.cs b/Content.Server/Nutrition/Components/DrinkComponent.cs
index 2dfc6c495d..b6d893ae02 100644
--- a/Content.Server/Nutrition/Components/DrinkComponent.cs
+++ b/Content.Server/Nutrition/Components/DrinkComponent.cs
@@ -1,4 +1,3 @@
-using Content.Shared.Chemistry.Reagent;
 using Content.Shared.Sound;
 using JetBrains.Annotations;
 using Robust.Shared.GameObjects;
@@ -7,6 +6,7 @@ using Robust.Shared.ViewVariables;
 using Content.Server.Nutrition.EntitySystems;
 using Content.Shared.FixedPoint;
 using Robust.Shared.Analyzers;
+using System.Threading;
 
 namespace Content.Server.Nutrition.Components
 {
@@ -50,8 +50,9 @@ namespace Content.Server.Nutrition.Components
         public float ForceFeedDelay = 3;
 
         /// <summary>
-        ///     If true, this drink has some DoAfter active (someone is being force fed).
+        ///     Token for interrupting a do-after action (e.g., force feeding). If not null, implies component is
+        ///     currently "in use".
         /// </summary>
-        public bool InUse = false;
+        public CancellationTokenSource? CancelToken;
     }
 }
diff --git a/Content.Server/Nutrition/Components/FoodComponent.cs b/Content.Server/Nutrition/Components/FoodComponent.cs
index b567e5cdd0..8d3e1fac19 100644
--- a/Content.Server/Nutrition/Components/FoodComponent.cs
+++ b/Content.Server/Nutrition/Components/FoodComponent.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Threading;
 using Content.Server.Chemistry.EntitySystems;
 using Content.Server.Nutrition.EntitySystems;
 using Content.Shared.FixedPoint;
@@ -55,9 +56,10 @@ namespace Content.Server.Nutrition.Components
         public float ForceFeedDelay = 3;
 
         /// <summary>
-        ///     If true, this food has some DoAfter active (someone is being force fed).
+        ///     Token for interrupting a do-after action (e.g., force feeding). If not null, implies component is
+        ///     currently "in use".
         /// </summary>
-        public bool InUse = false;
+        public CancellationTokenSource? CancelToken;
 
         [ViewVariables]
         public int UsesRemaining
diff --git a/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs b/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs
index b327c8c1a2..c2258c565b 100644
--- a/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs
+++ b/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs
@@ -16,6 +16,7 @@ using Content.Shared.Chemistry.Reagent;
 using Content.Shared.Database;
 using Content.Shared.Examine;
 using Content.Shared.FixedPoint;
+using Content.Shared.Hands;
 using Content.Shared.Interaction;
 using Content.Shared.Interaction.Helpers;
 using Content.Shared.Nutrition.Components;
@@ -54,12 +55,26 @@ namespace Content.Server.Nutrition.EntitySystems
             SubscribeLocalEvent<DrinkComponent, ComponentInit>(OnDrinkInit);
             SubscribeLocalEvent<DrinkComponent, LandEvent>(HandleLand);
             SubscribeLocalEvent<DrinkComponent, UseInHandEvent>(OnUse);
+            SubscribeLocalEvent<DrinkComponent, HandDeselectedEvent>(OnDrinkDeselected);
             SubscribeLocalEvent<DrinkComponent, AfterInteractEvent>(AfterInteract);
             SubscribeLocalEvent<DrinkComponent, ExaminedEvent>(OnExamined);
             SubscribeLocalEvent<SharedBodyComponent, ForceDrinkEvent>(OnForceDrink);
             SubscribeLocalEvent<ForceDrinkCancelledEvent>(OnForceDrinkCancelled);
         }
 
+        /// <summary>
+        ///     If the user is currently forcing someone do drink, this cancels the attempt if they swap hands or
+        ///     otherwise loose the item. Prevents force-feeding dual-wielding.
+        /// </summary>
+        private void OnDrinkDeselected(EntityUid uid, DrinkComponent component, HandDeselectedEvent args)
+        {
+            if (component.CancelToken != null)
+            {
+                component.CancelToken.Cancel();
+                component.CancelToken = null;
+            }
+        }
+
         public bool IsEmpty(EntityUid uid, DrinkComponent? component = null)
         {
             if(!Resolve(uid, ref component))
@@ -240,6 +255,14 @@ namespace Content.Server.Nutrition.EntitySystems
             if (!Resolve(uid, ref drink))
                 return false;
 
+            // if currently being used to force-feed, cancel that action.
+            if (drink.CancelToken != null)
+            {
+                drink.CancelToken.Cancel();
+                drink.CancelToken = null;
+                return true;
+            }
+
             if (!drink.Opened)
             {
                 _popupSystem.PopupEntity(Loc.GetString("drink-component-try-use-drink-not-open",
@@ -312,8 +335,12 @@ namespace Content.Server.Nutrition.EntitySystems
                 return false;
 
             // cannot stack do-afters
-            if (drink.InUse)
-                return false;
+            if (drink.CancelToken != null)
+            {
+                drink.CancelToken.Cancel();
+                drink.CancelToken = null;
+                return true;
+            }
 
             if (!EntityManager.HasComponent<SharedBodyComponent>(targetUid))
                 return false;
@@ -342,7 +369,8 @@ namespace Content.Server.Nutrition.EntitySystems
             _popupSystem.PopupEntity(Loc.GetString("drink-component-force-feed", ("user", userName)),
                 userUid, Filter.Entities(targetUid));
 
-            _doAfterSystem.DoAfter(new DoAfterEventArgs(userUid, drink.ForceFeedDelay, target: targetUid)
+            drink.CancelToken = new();
+            _doAfterSystem.DoAfter(new DoAfterEventArgs(userUid, drink.ForceFeedDelay, drink.CancelToken.Token, targetUid)
             {
                 BreakOnUserMove = true,
                 BreakOnDamage = true,
@@ -350,7 +378,7 @@ namespace Content.Server.Nutrition.EntitySystems
                 BreakOnTargetMove = true,
                 MovementThreshold = 1.0f,
                 TargetFinishedEvent = new ForceDrinkEvent(userUid, drink, drinkSolution),
-                BroadcastCancelledEvent = new ForceDrinkCancelledEvent(drink)
+                BroadcastCancelledEvent = new ForceDrinkCancelledEvent(drink),
             });
 
             // logging
@@ -359,7 +387,6 @@ namespace Content.Server.Nutrition.EntitySystems
             var drinkable = EntityManager.GetEntity(uid);
             _logSystem.Add(LogType.ForceFeed, LogImpact.Medium, $"{user} is forcing {target} to drink {drinkable}");
 
-            drink.InUse = true;
             return true;
         }
 
@@ -368,7 +395,10 @@ namespace Content.Server.Nutrition.EntitySystems
         /// </summary>
         private void OnForceDrink(EntityUid uid, SharedBodyComponent body, ForceDrinkEvent args)
         {
-            args.Drink.InUse = false;
+            if (args.Drink.Deleted)
+                return;
+
+            args.Drink.CancelToken = null;
             var transferAmount = FixedPoint2.Min(args.Drink.TransferAmount, args.DrinkSolution.DrainAvailable);
             var drained = _solutionContainerSystem.Drain(args.Drink.OwnerUid, args.DrinkSolution, transferAmount);
 
@@ -414,7 +444,7 @@ namespace Content.Server.Nutrition.EntitySystems
 
         private void OnForceDrinkCancelled(ForceDrinkCancelledEvent args)
         {
-            args.Drink.InUse = false;
+            args.Drink.CancelToken = null;
         }
     }
 }
diff --git a/Content.Server/Nutrition/EntitySystems/FoodSystem.cs b/Content.Server/Nutrition/EntitySystems/FoodSystem.cs
index 9876afd2e1..1f872ca1dc 100644
--- a/Content.Server/Nutrition/EntitySystems/FoodSystem.cs
+++ b/Content.Server/Nutrition/EntitySystems/FoodSystem.cs
@@ -9,7 +9,6 @@ using Content.Server.Popups;
 using Content.Shared.ActionBlocker;
 using Content.Shared.Administration.Logs;
 using Content.Shared.Body.Components;
-using Content.Shared.Chemistry.Components;
 using Content.Shared.Chemistry.Reagent;
 using Content.Shared.Database;
 using Content.Shared.FixedPoint;
@@ -23,10 +22,10 @@ using Robust.Shared.IoC;
 using Robust.Shared.Localization;
 using Robust.Shared.Player;
 using System.Collections.Generic;
-using System.Linq;
 using Robust.Shared.Utility;
 using Content.Server.Inventory.Components;
 using Content.Shared.Inventory;
+using Content.Shared.Hands;
 
 namespace Content.Server.Nutrition.EntitySystems
 {
@@ -50,12 +49,26 @@ namespace Content.Server.Nutrition.EntitySystems
 
             SubscribeLocalEvent<FoodComponent, UseInHandEvent>(OnUseFoodInHand);
             SubscribeLocalEvent<FoodComponent, AfterInteractEvent>(OnFeedFood);
+            SubscribeLocalEvent<FoodComponent, HandDeselectedEvent>(OnFoodDeselected);
             SubscribeLocalEvent<FoodComponent, GetInteractionVerbsEvent>(AddEatVerb);
             SubscribeLocalEvent<SharedBodyComponent, ForceFeedEvent>(OnForceFeed);
             SubscribeLocalEvent<ForceFeedCancelledEvent>(OnForceFeedCancelled);
             SubscribeLocalEvent<InventoryComponent, IngestionAttemptEvent>(OnInventoryIngestAttempt);
         }
 
+        /// <summary>
+        ///     If the user is currently force feeding someone, this cancels the attempt if they swap hands or otherwise
+        ///     loose the item. Prevents force-feeding dual-wielding.
+        /// </summary>
+        private void OnFoodDeselected(EntityUid uid, FoodComponent component, HandDeselectedEvent args)
+        {
+            if (component.CancelToken != null)
+            {
+                component.CancelToken.Cancel();
+                component.CancelToken = null;
+            }
+        }
+
         /// <summary>
         /// Eat item
         /// </summary>
@@ -120,6 +133,14 @@ namespace Content.Server.Nutrition.EntitySystems
             if (!Resolve(uid, ref component))
                 return false;
 
+            // if currently being used to force-feed, cancel that action.
+            if (component.CancelToken != null)
+            {
+                component.CancelToken.Cancel();
+                component.CancelToken = null;
+                return true;
+            }
+
             if (uid == userUid || //Suppresses self-eating
                 EntityManager.TryGetComponent<MobStateComponent>(uid, out var mobState) && mobState.IsAlive()) // Suppresses eating alive mobs
                 return false;
@@ -214,6 +235,9 @@ namespace Content.Server.Nutrition.EntitySystems
 
         private void AddEatVerb(EntityUid uid, FoodComponent component, GetInteractionVerbsEvent ev)
         {
+            if (component.CancelToken != null)
+                return;
+
             if (uid == ev.UserUid ||
                 !ev.CanInteract ||
                 !ev.CanAccess ||
@@ -244,6 +268,14 @@ namespace Content.Server.Nutrition.EntitySystems
             if (!Resolve(uid, ref food))
                 return false;
 
+            // if currently being used to force-feed, cancel that action.
+            if (food.CancelToken != null)
+            {
+                food.CancelToken.Cancel();
+                food.CancelToken = null;
+                return true;
+            }
+
             if (!EntityManager.HasComponent<SharedBodyComponent>(targetUid))
                 return false;
 
@@ -270,7 +302,8 @@ namespace Content.Server.Nutrition.EntitySystems
             _popupSystem.PopupEntity(Loc.GetString("food-system-force-feed", ("user", userName)),
                 userUid, Filter.Entities(targetUid));
 
-            _doAfterSystem.DoAfter(new DoAfterEventArgs(userUid, food.ForceFeedDelay, target: targetUid)
+            food.CancelToken = new();
+            _doAfterSystem.DoAfter(new DoAfterEventArgs(userUid, food.ForceFeedDelay, food.CancelToken.Token, targetUid)
             {
                 BreakOnUserMove = true,
                 BreakOnDamage = true,
@@ -287,13 +320,15 @@ namespace Content.Server.Nutrition.EntitySystems
             var edible = EntityManager.GetEntity(uid);
             _logSystem.Add(LogType.ForceFeed, LogImpact.Medium, $"{user} is forcing {target} to eat {edible}");
 
-            food.InUse = true;
             return true;
         }
 
         private void OnForceFeed(EntityUid uid, SharedBodyComponent body, ForceFeedEvent args)
         {
-            args.Food.InUse = false;
+            if (args.Food.Deleted)
+                return;
+
+            args.Food.CancelToken = null;
 
             if (!_bodySystem.TryGetComponentsOnMechanisms<StomachComponent>(uid, out var stomachs, body))
                 return;
@@ -433,7 +468,7 @@ namespace Content.Server.Nutrition.EntitySystems
 
         private void OnForceFeedCancelled(ForceFeedCancelledEvent args)
         {
-            args.Food.InUse = false;
+            args.Food.CancelToken = null;
         }
 
         /// <summary>